Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study
نویسندگان
چکیده
منابع مشابه
Microcirculatory alterations are associated with pulmonary dead-space fraction in moderate and severe ards
Introduction Shunt-induced hypoxemia is considered the primary pathophysiological abnormality and main diagnostic criteria of acute respiratory distress syndrome (ARDS). However, increases in dead-space ventilation (VD/VT) can also contribute to gas exchange alterations in ARDS. Systemic microcirculatory alterations described during inflammatory conditions are characterized by perfusion heterog...
متن کاملAssessment of dead-space ventilation in patients with acute respiratory distress syndrome: a prospective observational study.
BACKGROUND Physiological dead space (VD/VT) represents the fraction of ventilation not participating in gas exchange. In patients with acute respiratory distress syndrome (ARDS), VD/VT has prognostic value and can be used to guide ventilator settings. However, VD/VT is rarely calculated in clinical practice, because its measurement is perceived as challenging. Recently, a novel technique to cal...
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BACKGROUND There are few data regarding mechanical ventilation and ARDS in the ED. This could be a vital arena for prevention and treatment. METHODS This study was a multicenter, observational, prospective, cohort study aimed at analyzing ventilation practices in the ED. The primary outcome was the incidence of ARDS after admission. Multivariable logistic regression was used to determine the ...
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An elevated physiological dead space, calculated from measurements of arterial CO2 and mixed expired CO2, has proven to be a useful clinical marker of prognosis both for patients with acute respiratory distress syndrome and for patients with severe heart failure. Although a frequently cited explanation for an elevated dead space measurement has been the development of alveolar regions receiving...
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ژورنال
عنوان ژورنال: Annals of Intensive Care
سال: 2020
ISSN: 2110-5820
DOI: 10.1186/s13613-020-00651-1